Next-generation brain-machine interface for whole-brain input/output

Circuit-level brain disorders involve either dysfunction within brain regions (micro-circuits) or between interconnected regions (macro-circuits), which contributes to conditions like post-traumatic stress disorder, anxiety, schizophrenia and epilepsy.

Advances in the understanding of circuit function have led to targeted therapies, such as modulating specific neuronal populations for Parkinson's disease. Emerging technologies – combined with AI and bioengineering – and a precision neurotechnology approach promise less invasive and efficient interventions, redefining therapeutic possibilities for neurological and neuropsychological conditions.

Researchers will utilise Forest Neurotech's ultrasonic neural interface, 'Forest 1', for advanced brain imaging and neuromodulation. Measuring and modulating neural activity across different mood states, the team aims to develop a predictive model of affective brain states, shifting brain states towards clinically meaningful outcomes such as improved mood and reduced depression.

The project will look to recruit 30 individuals who have had craniectomies (where a portion of skull has been surgically removed to relieve pressure in the brain following a traumatic brain injury or stroke) and test the safety and tolerability of Forest 1. Researchers will develop computational models by measuring and modulating brain activity.

The Forest 1 device will be placed on the surface of the skin on the head and measure the patient's brain activity while using ultrasound to stimulate different parts of it.